Current Issue : October-December Volume : 2020 Issue Number : 4 Articles : 3 Articles
The present study was designed to investigate the potential of a novel class of vesicular system ‘proniosome’ as a carrier for transdermal delivery of loratadine proniosomal formulations. It was prepared by co-acervation phase separation method. The influence of factors like lipid concentration, cholesterol amount and drug content were studied. Span 60 was the most appropriate surfactant and yielded vesicle size and percentage encapsulation efficiency respectively. The developed formulation was characterized for drug release, zeta potential, particle size, release kinetics and ex-vivo permeation studies. The in-vitro loratadine proniosomes exhibited sustained release for 7 hrs. Zeta potential was found to be -52.3mV which indicates the stability of the formulation. The proniosomes F3 formulation shows entrapment efficiency of 90%. The skin permeation showed same pattern as that of in-vitro release profile across the cellophane membrane for 7 hr. stability studies indicated no significant changes in formulation at accelerated condition after a month....
Nanostructured lipid carriers of cefixime trihydrate were prepared by hot melt micro emulsification method. The hot melt was prepared by heating the drug with a blend of solid lipid and liquid lipids: oleic and paraffin wax /bees wax is used as solid lipid and liquid lipids. FTIR studies of pure drug and formulations showed there was no significant change in the signal peaks of drugs; this indicates that there were no interactions between the drug and the formulation excipients. The optimized formulations were characterized for particle size, in-vitro release, entrapment efficiency, drug content and stability studies. The particle size analysis by nano zeta sizer showed that the average particle size of the cefixime trihydrate is 350.7 nm. The PDI value 0.500 indicated good dispersion of uniformly sized NLCâ??s. Comparison of entrapment efficiency and drug release of various formulations established that the NLC prepared with paraffin wax showed significantly higher entrapment efficiency and prolonged drug release compared to the NLC prepared with beeswax. The drug release studies show initial bust release at 67.28 % at the end of 360 min. This indicated that incorporation of cefixime trihydrate into NLC sustained the drug release. The stability studies indicated that formulations stored at refrigeration temperature and room temperature showed no significant drug loss and no significant changes in the drug release pattern, after a period of 4 weeks....
The rationale of the present study was to formulate, characterize and evaluate the polymeric nanoparticle of rosuvastatin calcium, a poorly water-soluble and low bioavailable drug with the intend of recuperating aqueous solubility consequently the dissolution rate. Rosuvastatin calcium (ROSCa) biodegradable polymeric nanoparticles were prepared by ionotropic gelation technique. Material and polymer used in the preparation of biodegradable polymeric nanoparticles were tween 80 %, chitosan (CH) and sodium tripolyphosphate (STPP). Different ratios of polymers were used in the formulation of rosuvastatin calcium formulations (RF1 to RF9). The prepared nanoparticles were characterized by drug-excipient interactions Fourier-transform infrared spectroscopy (FTIR) and evaluated for percent drug content uniformity, particle size, zeta potential, % entrapment efficacy, in-vitro drug release and short-term stability. RF4 formulation exhibited 88.49 % of drug released within 10 hrs and exhibited Korsmeyer Peppas drug release kinetics. Stability studies indicated RF4 formulation exhibited better stability....
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